Silent Myocardial Infarction in Hypereosinophilic Syndrome Overlapped with JAK2-Mediated Essential Thrombocytosis: A Case Report

A 61-year-old male with chronic cough, paraesthesia of the extremities, and sinusitis presented for acute worsening symptoms despite initial treatment antibiotics prednisone. Emergency department evaluation revealed mild elevated troponin without ECG changes in absence coronary symptoms, but markedly eosinophil count an abnormal chest CT. nuclear stress test basal inferoseptal dyskinesis fixed apical defect. Left heart catheterisation multiple stenosis requiring intervention. Further extensive work-up confirmed a diagnosis hypereosinophilic syndrome complicated respiratory, cardiac, gastroenterological, neurological involvement. The patient was initially treated high dose intravenous steroid hydroxyurea. Flow cytometry negative FIP1L1-PDGFRA gene rearrangement, positive JAK2 V617F mutation perinuclear antineutrophil cytoplasmic antibodies/cytoplasmic antibodies, indicating possible overlap eosinophilic granulomatosis polyangiitis.